GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs670523 | 1 | rs670523 | chr1:155878732 | FDPS | chr1:155278539-155290457:+ | -0.21 | -4.33 | 1.81E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs670523 | 1 | rs670523 | chr1:155878732 | RIT1 | chr1:155867601-155881177:- | 0.19 | 4.16 | 3.84E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs9309473 | 1 | rs6705489 | chr2:73648811 | ALMS1P | chr2:73872046-73912692:+ | 0.74 | 11.44 | 6.03E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6705489 | chr2:73648811 | NAT8 | chr2:73867850-73869537:- | 0.39 | 5.99 | 4.21E-9 | Metabolite levels |
| THCA | cis | rs754466 | 1 | rs67059283 | chr10:79683235 | DLG5 | chr10:79550551-79686348:- | 0.23 | 4.01 | 6.94E-5 | Liver enzyme levels (gamma-glutamyl transferase) |
| THCA | cis | rs6547741 | 1 | rs6706610 | chr2:27778091 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.51 | 0.000486 | Oral cavity cancer |
| THCA | cis | rs67073037 | 1 | rs67073037 | chr2:29119585 | TRMT61B | chr2:29072690-29093175:- | 0.39 | 6.83 | 2.55E-11 | Breast cancer (estrogen-receptor negative);Breast cancer |
| THCA | cis | rs4664308 | 1 | rs6707458 | chr2:160914540 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.89 | 1.35E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | ALMS1P | chr2:73872046-73912692:+ | 0.71 | 11.38 | 9.89E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | NAT8 | chr2:73867850-73869537:- | 0.38 | 6.04 | 3.13E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | TPRKB | chr2:73956957-73964517:- | -0.18 | -4.59 | 5.76E-6 | Metabolite levels |
| THCA | cis | rs4372836 | 1 | rs6707848 | chr2:28988083 | PPP1CB | chr2:28974612-29025805:+ | 0.16 | 4.09 | 5.15E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs6707848 | chr2:28988083 | TRMT61B | chr2:29072690-29093175:- | -0.53 | -10.76 | 2.47E-24 | Body mass index |
| THCA | cis | rs994533 | 1 | rs6707903 | chr2:218276836 | DIRC3 | chr2:218148748-218621316:- | 0.21 | 5.07 | 5.67E-7 | Height |
| THCA | cis | rs2288073 | 1 | rs6708328 | chr2:24412413 | C2orf84 | chr2:24397531-24414566:+ | 0.3 | 4.55 | 6.73E-6 | Venous thromboembolism (SNP x SNP interaction) |